Effect of Erythromycin on Neutrophil Adhesion Molecules
نویسندگان
چکیده
منابع مشابه
[Effect of erythromycin on neutrophil chemotactic activity from human monocytes].
序 文 エ リスロマイシン(以下EM)の 少量長期持続投 与が,び まん性汎細気管支炎(以 下DPB)を は じ め とした慢性気道感染症に有効であることはほぼ 確立 されている.そ の作用機序の一つ として,EM 投与前後で気管支肺胞洗浄液(以 下BALF)中 の 好中球走化因子(以 下NCF)活 性が低下する1)こ とか ら,EMは 肺局所 におけるNCF活 性を抑制 している可能性が考えられる.そ こで,肺 胞マク ロファージと同様に,イ ンターロイキソ8(IL8) などのNCFを 分泌することが明らかとなってい る末梢血単球 に対す るEMの 影響 について検討 した. 材料および方法 単球は,健 康人末梢血 よ りFicoll-Conray比 重 遠心法にて分離 した後,単 核球の層を採取し,10% FCS入 りRPMI1640培 養液に浮遊させ,培 養フラ スコにて1時 ...
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ژورنال
عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases
سال: 1993
ISSN: 1884-569X,0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.67.7